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NCBI Bookshelf. Although there are many possible causes of human disease, family history is often one of the strongest risk factors for common disease complexes such as cancer, cardiovascular disease CVD , diabetes, autoimmune disorders, and psychiatric illnesses. Inherited genetic variation within families clearly contributes both directly and indirectly to the pathogenesis of disease. This chapter focuses on what is known or theorized about the direct link between genes and health and what still must be explored in order to understand the environmental interactions and relative roles among genes that contribute to health and illness.
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